Posttraumatic Stress Disorder (PTSD)
Conditions
Brief summary
For substudy A, the main study parameters are (1) early life adversity, (2) Hypothalamic-pituitary-adrenal axis functioning, and (3) epigenetic mechanisms. For substudy B, the main study parameter regards retention of the safety memory within the VR contextual fear conditioning environment.
Detailed description
For substudy A, this includes (1) salivary cortisol response curve to the SECPT ( a validated stress test) and (2) treatment response to focused treatment for PTSD. For substudy B, this includes the following MRI endpoints (1) BOLD-fMRI response during fear extinction, (2) BOLD-fMRI general amygdala responsiveness during viewing of emotional faces (3) Resting state fMRI functional coupling between vmPFC and amygdala(4) Structural MRI (T1-weighted MP-RAGE) and DTI scans.
Interventions
DRUGPlacebo: PL1
DRUGRoute of administration: Oral use
DRUGHydrocortison DMB 20 mg
DRUGtabletten
Sponsors
Stichting Radboud universitair medisch centrum
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| For substudy A, the main study parameters are (1) early life adversity, (2) Hypothalamic-pituitary-adrenal axis functioning, and (3) epigenetic mechanisms. For substudy B, the main study parameter regards retention of the safety memory within the VR contextual fear conditioning environment. | — |
Secondary
| Measure | Time frame |
|---|---|
| For substudy A, this includes (1) salivary cortisol response curve to the SECPT ( a validated stress test) and (2) treatment response to focused treatment for PTSD. For substudy B, this includes the following MRI endpoints (1) BOLD-fMRI response during fear extinction, (2) BOLD-fMRI general amygdala responsiveness during viewing of emotional faces (3) Resting state fMRI functional coupling between vmPFC and amygdala(4) Structural MRI (T1-weighted MP-RAGE) and DTI scans. | — |
Countries
Netherlands
Outcome results
None listed