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A phase III, randomized, double-masked, placebocontrolled, parallel-group, multicenter study of the safety and efficacy of OT-101 (Atropine Sulfate 0.01%) in treating the progression of myopia in pediatric subjects

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-516315-24-00
Acronym
OT-101-001
Enrollment
210
Registered
2024-11-26
Start date
2022-05-27
Completion date
Unknown
Last updated
2025-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

myopia

Brief summary

Percentage of study eyes with a -0.75 D of progressive myopia at Month 36 defined as an increase in spherical equivalent of -0.75 D or greater (i.e., change from baseline ≥ -0.75) as assessed by cycloplegic autorefraction.

Detailed description

Change from baseline to Month 36 in study eye spherical equivalent (D) as assessed by cycloplegic autorefraction, Change from baseline to Month 36 in study eye axial length as measured by cycloplegic biometry (a device will be selected and the same device to be used throughout the duration of this study)

Interventions

DRUGAtropine Sulfate 0.01% Ophthalmic Solution
DRUGThe placebo for this trial will be composed of excipients used to manufacture the investigational drug but without the active drug substance.

Sponsors

Ocumension (Hong Kong) Ltd.
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
0 Years to 17 Years

Design outcomes

Primary

MeasureTime frame
Percentage of study eyes with a -0.75 D of progressive myopia at Month 36 defined as an increase in spherical equivalent of -0.75 D or greater (i.e., change from baseline ≥ -0.75) as assessed by cycloplegic autorefraction.

Secondary

MeasureTime frame
Change from baseline to Month 36 in study eye spherical equivalent (D) as assessed by cycloplegic autorefraction, Change from baseline to Month 36 in study eye axial length as measured by cycloplegic biometry (a device will be selected and the same device to be used throughout the duration of this study)

Countries

Hungary, Ireland, Poland, Slovakia, Spain

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026