Patients with connective tissue diseases at high risk of interstial lung disease
Conditions
Brief summary
The following measures will be evaluated in FAPI PET-CT: pattern and distribution of FAPI uptake, mean and maximum Standardized Uptake Value (SUV mean and SUV max) of pulmonary fibrotic lesions, fibrotic active volume (FAV), total fibrosis (calculated as the product of SUV mean and the fibrotic active volume), uptake ratio between fibrotic and healthy lung tissue. These measures will be compared between CTD-ILD patients with and without progressive phenotypes at the 12-month follow-up
Detailed description
AI-collected measures of lung anatomy (including lung texture, airway, and vascular measures) and serum EV single-protein quantity and RNA expression measures, Exploratory endpoint: BALF EV single-protein quantity and RNA expression measures
Interventions
None listed
Sponsors
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The following measures will be evaluated in FAPI PET-CT: pattern and distribution of FAPI uptake, mean and maximum Standardized Uptake Value (SUV mean and SUV max) of pulmonary fibrotic lesions, fibrotic active volume (FAV), total fibrosis (calculated as the product of SUV mean and the fibrotic active volume), uptake ratio between fibrotic and healthy lung tissue. These measures will be compared between CTD-ILD patients with and without progressive phenotypes at the 12-month follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| AI-collected measures of lung anatomy (including lung texture, airway, and vascular measures) and serum EV single-protein quantity and RNA expression measures, Exploratory endpoint: BALF EV single-protein quantity and RNA expression measures | — |
Countries
Italy
Outcome results
None listed