only Lung Squamous Cell Carcinoma or Adenocarcinoma)., or Resectable Non-small cell lung cancer (NSCLC, Patients affected by Resectable Head and Neck (HN) cancer (only Squamous Cell Carcinoma of the oral cavity or larynx)
Conditions
Brief summary
The biological effect of HCQ will be evaluated using immunohistochemical studies performed for known autophagic and immunological markers (CD3, CD8, CD163, p53, p62, LC3) with quantification of positivity / total cells, intensity, expression pattern. Eventual tumor cytoarchitectural modification and tumor lymphocyte infiltrate will be evaluated and scored using standard grading system.
Interventions
DRUGHYDROXYCHLOROQUINE
Sponsors
Ospedale San Raffaele S.r.l.
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The biological effect of HCQ will be evaluated using immunohistochemical studies performed for known autophagic and immunological markers (CD3, CD8, CD163, p53, p62, LC3) with quantification of positivity / total cells, intensity, expression pattern. Eventual tumor cytoarchitectural modification and tumor lymphocyte infiltrate will be evaluated and scored using standard grading system. | — |
Countries
Italy
Outcome results
None listed