Use of Isoprenaline with Epinephrine During Out-of-Hospital Cardiac Arrest with Non-Shockable Rhytm (EPISO)

Status

Not yet recruiting

Phases

Phase 3

Study type

Interventional

Source

EU CTIS

Registry ID

CTIS2024-516074-29-01

Enrollment

1178

Registered

2025-08-11

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac arrest

Brief summary

Sustained return of spontaneous circulation of at least 20 minutes.

Detailed description

Conversion from non-shockable to shockable rhythm, Favorable neurological outcome at hospital discharge, ROSC at hospital arrival, Thirty-day survival, Favorable neurological outcome at 90 days.

Interventions

DRUGSODIUM CHLORIDE

DRUGISOPRENALINE

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Sustained return of spontaneous circulation of at least 20 minutes.	—

Secondary

Measure	Time frame
Conversion from non-shockable to shockable rhythm, Favorable neurological outcome at hospital discharge, ROSC at hospital arrival, Thirty-day survival, Favorable neurological outcome at 90 days.	—

Countries

Denmark

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026