Low-cardiac output syndrome (LCOS)
Conditions
Brief summary
The primary outcome will be the reduction of the occurrence of postoperative low-cardiac output syndrome, defined following a recent JAMA publication (Cholley 2017) as the presence of at least one of the following:, need of prolonged catecholamine infusion (persisting beyond 48 hours after the initiation of the study drug);, need of circulatory mechanical assist devices in the postoperative period (if an intraaortic balloon pump was inserted preventively, the criteria will be met if patients are not weaned from the balloon within 96 hours);, need for renal replacement therapy at any time during the intensive care unit stay.
Detailed description
Patients requiring prolonged (>48 h) catecholamine infusion;, patients with increased postoperative cardiac biomarkers (Troponin I or T);, patients with a reduction in left ventricular ejection fraction;, number of patients readmitted to hospital for cardiac reasons;, EQ-5D-5L questionnaire;, death.
Interventions
DRUGLandiobloc 300 mg polvere per soluzione per infusione
DRUGSODIO CLORURO 0
Sponsors
Ospedale San Raffaele S.r.l.
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be the reduction of the occurrence of postoperative low-cardiac output syndrome, defined following a recent JAMA publication (Cholley 2017) as the presence of at least one of the following:, need of prolonged catecholamine infusion (persisting beyond 48 hours after the initiation of the study drug);, need of circulatory mechanical assist devices in the postoperative period (if an intraaortic balloon pump was inserted preventively, the criteria will be met if patients are not weaned from the balloon within 96 hours);, need for renal replacement therapy at any time during the intensive care unit stay. | — |
Secondary
| Measure | Time frame |
|---|---|
| Patients requiring prolonged (>48 h) catecholamine infusion;, patients with increased postoperative cardiac biomarkers (Troponin I or T);, patients with a reduction in left ventricular ejection fraction;, number of patients readmitted to hospital for cardiac reasons;, EQ-5D-5L questionnaire;, death. | — |
Countries
Italy
Outcome results
None listed