Coronary artery disease
Conditions
Brief summary
Mean percentage change in coronary arteries target to background ratio (TBRmax) and monocyte activation marker protein expression between the treatment and placebo group, at the primary analysis time point of 20 weeks, compared to baseline.
Detailed description
Difference in PCAT (CCTA derived) after ziltivekimab treatment, Correlation between changes in coronary 68Ga-DOTATATE uptake and anatomical plaque changes on CCTA., Difference in 68Ga-DOTATATE SUVmax of bone marrow and spleen after treatment., Difference in 68Ga-DOTATATE TBRmax of ascending aorta after treatment., The impact of ziltivekimab on monocyte phenotype in transendothelial migration (TEM) capacity and transcriptome profile., The mean percentage change in plasmatic proteins before and after ziltivekimab treatment., The impact of ziltivekimab on inflammation in plasma cytokine and chemokine levels.
Interventions
DRUGZiltivekimab B 15 mg/mL DV3430-C1
Sponsors
Stichting Amsterdam UMC
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean percentage change in coronary arteries target to background ratio (TBRmax) and monocyte activation marker protein expression between the treatment and placebo group, at the primary analysis time point of 20 weeks, compared to baseline. | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference in PCAT (CCTA derived) after ziltivekimab treatment, Correlation between changes in coronary 68Ga-DOTATATE uptake and anatomical plaque changes on CCTA., Difference in 68Ga-DOTATATE SUVmax of bone marrow and spleen after treatment., Difference in 68Ga-DOTATATE TBRmax of ascending aorta after treatment., The impact of ziltivekimab on monocyte phenotype in transendothelial migration (TEM) capacity and transcriptome profile., The mean percentage change in plasmatic proteins before and after ziltivekimab treatment., The impact of ziltivekimab on inflammation in plasma cytokine and chemokine levels. | — |
Countries
Netherlands
Outcome results
None listed