Pharmacokinetics of antibiotics in cerebrospinal fluid of children with external ventricular drain

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

EU CTIS

Registry ID

CTIS2024-515791-12-00

Enrollment

Registered

2024-09-08

Start date

2018-08-30

Completion date

2026-01-08

Last updated

2024-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients with external ventricular drain

Brief summary

Maximum concentration (Cmax) in CSF, time to maximum concentration (tmax) in CSF, area under the concentration time curve from zero to last observed concentration (AUC0-τ) in CSF, half-life (t1/2) in CSF

Interventions

DRUGLinezolid Kabi 2 mg/ml Infusionslösung

DRUGVancomycin Hikma 500 mg - Pulver für ein Konzentrat zur Herstellung einer Infusionslösung

DRUGCefuroxim „Astro“ - Trockenstechampulle

DRUGKefzol 1 g – Trockenstechampullen

DRUGPiperacillin/Tazobactam Kabi 4 g/0

DRUG5 g Pulver zur Herstellung einer Infusionslösung

DRUGGentamicin Sandoz 80 mg – Ampullen

DRUGStandacillin 1 g – Pulver zur Herstellung einer Injektions-/Infusionslösung

Eligibility

Sex/Gender

All

Age

0 Years to 17 Years

Design outcomes

Primary

Measure	Time frame
Maximum concentration (Cmax) in CSF, time to maximum concentration (tmax) in CSF, area under the concentration time curve from zero to last observed concentration (AUC0-τ) in CSF, half-life (t1/2) in CSF	—

Countries

Austria

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026