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The Effect of tinzaparin on Biomarkers in FIGO Stage III-IV Ovarian Cancer Patients Undergoing Neoadjuvant Chemotherapy – A randomized pilot study

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-515450-24-00
Acronym
TABANETOC
Enrollment
40
Registered
2024-10-25
Start date
2022-04-22
Completion date
Unknown
Last updated
2024-10-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epithelial ovarian cancer

Brief summary

Level of CA-125 measured before cycles one-four of chemotherapy and preoperatively before DPDS.

Detailed description

Levels of hemoglobin, platelets, leucocytes, CRP, albumin, IL-6 and VEGF before every cycle of chemotherapy, preoperatively before DPDS and three weeks after the last cycle of chemotherapy., CA-125 measured before cycles five-seven of chemotherapy and three weeks after the last cycle of chemotherapy, The compliance to tinzaparin injections and occurrence of adverse events related to tinzaparin will be evaluated., Objectively confirmed VTE, i.e. pulmonary embolism, lower-limb deep vein thrombosis or upper extremity deep vein thrombosis. Death due to VTE.

Interventions

DRUGTINZAPARIN

Sponsors

Region Oestergoetland
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Level of CA-125 measured before cycles one-four of chemotherapy and preoperatively before DPDS.

Secondary

MeasureTime frame
Levels of hemoglobin, platelets, leucocytes, CRP, albumin, IL-6 and VEGF before every cycle of chemotherapy, preoperatively before DPDS and three weeks after the last cycle of chemotherapy., CA-125 measured before cycles five-seven of chemotherapy and three weeks after the last cycle of chemotherapy, The compliance to tinzaparin injections and occurrence of adverse events related to tinzaparin will be evaluated., Objectively confirmed VTE, i.e. pulmonary embolism, lower-limb deep vein thrombosis or upper extremity deep vein thrombosis. Death due to VTE.

Countries

Sweden

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026