Postoperative anti-infective strategy following pancreaticoduodenectomy in patients with preoperative biliary stent FRENCH24 ANIS

Conditions

Patients with preoperative biliary stent treated by pancreaticoduodenectomy

Brief summary

The primary endpoint is the presence of organ/space SSI determined according to the Centers for Disease Control and Prevention’s national nosocomial infections surveillance system. Organ/space SSIs included postoperative pancreatic fistula (POPF) and bile leakage, with positive culture results.

Detailed description

Infectious complications at post-operative day 90 Overall postsurgical morbidity, graded according to the Dindo/Clavien classification and CCI score at post operative day 90 Specific morbidity due to pancreatic fistula, graded according to the International Study Group of Pancreatic Fistula (ISGPF) criteria Readmission rates at post-operative day 90 Duration of hospitalization, Correlation between post-operative bacteriological samples and intraoperative bile samples, Bacteriological resistance profiles, Incidence of fungal contamination, Correlation between bacteriological and fungal contaminations, Incremental cost per infectious complications avoided

Lilian Schwarz, André Gillibert, Julie Rondeaux, Elie Lacroix, António Sá Cunha et al. (6 authors)

BMC Surgery2024-08-222 citations

10.1186/s12893-024-02507-y

Interventions

DRUGPIPERACILLINE/TAZOBACTAM KABI 4 g/ 500 mg

DRUGpoudre pour solution pour perfusion.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
The primary endpoint is the presence of organ/space SSI determined according to the Centers for Disease Control and Prevention’s national nosocomial infections surveillance system. Organ/space SSIs included postoperative pancreatic fistula (POPF) and bile leakage, with positive culture results.	—

Secondary

Measure	Time frame
Infectious complications at post-operative day 90 Overall postsurgical morbidity, graded according to the Dindo/Clavien classification and CCI score at post operative day 90 Specific morbidity due to pancreatic fistula, graded according to the International Study Group of Pancreatic Fistula (ISGPF) criteria Readmission rates at post-operative day 90 Duration of hospitalization, Correlation between post-operative bacteriological samples and intraoperative bile samples, Bacteriological resistance profiles, Incidence of fungal contamination, Correlation between bacteriological and fungal contaminations, Incremental cost per infectious complications avoided	—

Measure

Time frame

Infectious complications at post-operative day 90 Overall postsurgical morbidity, graded according to the Dindo/Clavien classification and CCI score at post operative day 90 Specific morbidity due to pancreatic fistula, graded according to the International Study Group of Pancreatic Fistula (ISGPF) criteria Readmission rates at post-operative day 90 Duration of hospitalization, Correlation between post-operative bacteriological samples and intraoperative bile samples, Bacteriological resistance profiles, Incidence of fungal contamination, Correlation between bacteriological and fungal contaminations, Incremental cost per infectious complications avoided

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Countries

France

Outcome results

None listed