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A Phase I/II Study in Healthy Subjects to Evaluate the Safety, Tolerability, and Imaging Quality of Single Ascending IV Doses of HarMono-T Contrast Agent During Ultrasound of the Kidney

Status
Withdrawn
Phases
Phase 1Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-514924-17-00
Acronym
CTSP-001
Enrollment
20
Registered
2025-08-12
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

for diagnostic purposes (to assess indeterminate kidney lesions), Ultrasound contrast agent

Brief summary

The occurrence of adverse reactions until 7±2days post injection, 12-lead ECG, Vital signs, Clinical laboratory parameters (haematology; renal and hepatic functions)

Detailed description

Parametric imaging (Time to Peak (s), Peak Enhance-ment (dB)), Parametric imaging (Wash-in Area Under the Curve (dB), Wash-out Area Under the Curve (dB)), Parametric imaging (Peak Enhancement (dB)), CEUS at 30minutes post dose is to confirm total clearing of HarMono-T

Interventions

DRUGHarMono-T 5 microlitres/mL gas and solvent for dispersion for injection/infusion

Sponsors

Solstice Pharmaceuticals B.V.
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
18 Years to 64 Years

Design outcomes

Primary

MeasureTime frame
The occurrence of adverse reactions until 7±2days post injection, 12-lead ECG, Vital signs, Clinical laboratory parameters (haematology; renal and hepatic functions)

Secondary

MeasureTime frame
Parametric imaging (Time to Peak (s), Peak Enhance-ment (dB)), Parametric imaging (Wash-in Area Under the Curve (dB), Wash-out Area Under the Curve (dB)), Parametric imaging (Peak Enhancement (dB)), CEUS at 30minutes post dose is to confirm total clearing of HarMono-T

Countries

Germany

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026