Short course antibiotic treatment of Gram-negative bacteremia: A multicenter, randomized, non-blinded, non-inferiority interventional study

Conditions

Gram-negative Bacteremia

Brief summary

90-day survival without clinical or microbiological failure to treatment

Detailed description

Mortality (timeframe 14, 30 and 90 days), Total duration of antibiotic treatment (timeframe 90 days), Type of antibiotic treatment (timeframe 90 days), Duration of antibiotic treatment (timeframe 90 days), Total length of hospital stay (timeframe 90 days), Hospital re-admission, Antibiotic adverse events (timeframe 30 and 90 days), Use of antimicrobials after discharge (timeframe 90 days), Severe adverse events (timeframe 90 days), Acute kidney injury (timeframe 90 days), Clostridioides difficile infection - Number of participants with Clostridioides difficile infection (timeframe 90 days), Multidrug-resistance organism: Multidrug-resistance organism defined as identification of resistant bacteria in a clinical specimen obtained only from a clinical infection. (timeframe 90 days)

Related papers

No related papers found yet.

Interventions

DRUGSelexid

DRUGCiprofloxacin Fresenius Kabi

DRUGAmpicillin "PCD"

DRUGpulver til injektionsvæske

DRUGopløsning

DRUGMeropenem ”Stada”

DRUGpulver til injektions- og infusionsvæske

DRUGSulfametizol ”Alternova”

DRUGtabletter

DRUGBioclavid

DRUGfilmovertrukne tabletter

DRUGPiperacillin/Tazobactam "Stragen"

DRUGpulver til infusionsvæske

DRUGCiprofloxacin "HEXAL"

DRUGCeftazidim "Fresenius Kabi"

DRUGHexamycin

DRUGinjektionsvæske

DRUGErtapenem Fresenius Kabi

DRUGSulfametoxazol med trimetoprim SAD

DRUGNebcina

DRUGNitrofurantoin "EQL Pharma"

DRUGTrimopan

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
90-day survival without clinical or microbiological failure to treatment	—

Secondary

Measure	Time frame
Mortality (timeframe 14, 30 and 90 days), Total duration of antibiotic treatment (timeframe 90 days), Type of antibiotic treatment (timeframe 90 days), Duration of antibiotic treatment (timeframe 90 days), Total length of hospital stay (timeframe 90 days), Hospital re-admission, Antibiotic adverse events (timeframe 30 and 90 days), Use of antimicrobials after discharge (timeframe 90 days), Severe adverse events (timeframe 90 days), Acute kidney injury (timeframe 90 days), Clostridioides difficile infection - Number of participants with Clostridioides difficile infection (timeframe 90 days), Multidrug-resistance organism: Multidrug-resistance organism defined as identification of resistant bacteria in a clinical specimen obtained only from a clinical infection. (timeframe 90 days)	—

Measure

Time frame

Mortality (timeframe 14, 30 and 90 days), Total duration of antibiotic treatment (timeframe 90 days), Type of antibiotic treatment (timeframe 90 days), Duration of antibiotic treatment (timeframe 90 days), Total length of hospital stay (timeframe 90 days), Hospital re-admission, Antibiotic adverse events (timeframe 30 and 90 days), Use of antimicrobials after discharge (timeframe 90 days), Severe adverse events (timeframe 90 days), Acute kidney injury (timeframe 90 days), Clostridioides difficile infection - Number of participants with Clostridioides difficile infection (timeframe 90 days), Multidrug-resistance organism: Multidrug-resistance organism defined as identification of resistant bacteria in a clinical specimen obtained only from a clinical infection. (timeframe 90 days)

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Countries

Denmark

Outcome results

None listed