Pooled human plasma vs. Crystalloid in the fluid management of children undergoing instrumented spinal fusion for scoliosis. A double-blind, randomized clinical trial.

Neuromuscular scoliosis (NMS), Adolescent idiopathic scoliosis (AIS)

Primary outcome is the intraoperative blood loss (blood loss in mL after wound closure).

Secondary outcomes include need for allogenic red blood cell infusion (percentage of patients at hospital release, health-related quality of life (Scoliosis Research Society 24 outcome questionnaire), postoperative pain (48-hour opioid consumption, pain visual analogue score), operative time (hours), drain output (mL), hidden blood loss (mL), hospital stay, and complications (skin reactions, TRALI, deep surgical site infection).

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Finland