HALT : Influence of Human Albumin supplementation on kidney dysfunction after Liver Transplantation

Conditions

Liver transplantation

Brief summary

Occurrence of Acute Kindey Injury during the first 7 days after liver transplantation (KDIGO criteria)

Detailed description

Occurrence and Severity of each Acute Kindey Injury during the first 7 days after liver transplantation (KDIGO Criteria), Hospital length of stay after liver transplantation defined by standardized checklist of discharged criteria, Postoperative Tacrolimus-induced neurotoxicity at D28, Discontinuation of anticalcineurin inhibitor at D28., Occurrence of postoperative infections at D28, Acute graft rejection (biopsy proved) at D28, Occurrence of early graft dysfunction (Olthoff criteria), Duration of mechanical ventilation at D28, Occurrence of reintubation at D28, Duration of Intensive Care Unit length of stay up to D28, Occurence of Intensive Care Unit readmission after discharge of Intensive Care Unit up to D28, Mortality within the first 28 days following surgery, Defined as a lymphocyte count less than 1.2× 103 cells/µL, Using flow cytometry, Using the Seahorse analyzer measuring mitochondrial respiration, Measured using expression of HLA-DR on peripheral monocytes, plasmatic levels of IL-10, MDSC, RNA seq analysis on peripheral blood mononuclear cell, Plasmatic levels of IL-6

Related papers

No related papers found yet.

Papers published before 2007-09-01 may not appear yet. Historical indexing is in progress.

Interventions

DRUGHUMAN ALBUMIN SOLUTION

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Occurrence of Acute Kindey Injury during the first 7 days after liver transplantation (KDIGO criteria)	—

Secondary

Measure	Time frame
Occurrence and Severity of each Acute Kindey Injury during the first 7 days after liver transplantation (KDIGO Criteria), Hospital length of stay after liver transplantation defined by standardized checklist of discharged criteria, Postoperative Tacrolimus-induced neurotoxicity at D28, Discontinuation of anticalcineurin inhibitor at D28., Occurrence of postoperative infections at D28, Acute graft rejection (biopsy proved) at D28, Occurrence of early graft dysfunction (Olthoff criteria), Duration of mechanical ventilation at D28, Occurrence of reintubation at D28, Duration of Intensive Care Unit length of stay up to D28, Occurence of Intensive Care Unit readmission after discharge of Intensive Care Unit up to D28, Mortality within the first 28 days following surgery, Defined as a lymphocyte count less than 1.2× 103 cells/µL, Using flow cytometry, Using the Seahorse analyzer measuring mitochondrial respiration, Measured using expression of HLA-DR on peripheral monocytes, plasmatic levels	—

Measure

Time frame

Occurrence and Severity of each Acute Kindey Injury during the first 7 days after liver transplantation (KDIGO Criteria), Hospital length of stay after liver transplantation defined by standardized checklist of discharged criteria, Postoperative Tacrolimus-induced neurotoxicity at D28, Discontinuation of anticalcineurin inhibitor at D28., Occurrence of postoperative infections at D28, Acute graft rejection (biopsy proved) at D28, Occurrence of early graft dysfunction (Olthoff criteria), Duration of mechanical ventilation at D28, Occurrence of reintubation at D28, Duration of Intensive Care Unit length of stay up to D28, Occurence of Intensive Care Unit readmission after discharge of Intensive Care Unit up to D28, Mortality within the first 28 days following surgery, Defined as a lymphocyte count less than 1.2× 103 cells/µL, Using flow cytometry, Using the Seahorse analyzer measuring mitochondrial respiration, Measured using expression of HLA-DR on peripheral monocytes, plasmatic levels

—

Countries

France

Outcome results

None listed