(Pre-BCGvacc) BCG vaccination: can pre-vaccination immune status predict outcome?

Conditions

health volunteerst

Brief summary

Induction of mycobacterial growth control measured in vitro by MGIA (1 log reduction post vaccination compared to inoculum). Level of control in MGIA will be used as classifier to assess pre-vaccination functional status.

Detailed description

Imaging of dermal biopsies and correlation of relative subset distribution with functional mycobacterial growth control in MGIA. Frequencies of subsets in the dermis will be correlated with MGIA control capacity., Correlates of protection for both BCG (MGIA as best available correlate) and Rabipur (neutralizing antibodies) vaccinations will be compared and correlated., Correlation between cell frequencies and functional read outs prevaccination and at multiple post vaccination time points, Correlation of metabolic state to effector immune responses such as measured by MGIA and intracellular cytokine secretion.

Related papers

No related papers found yet.

Papers published before 2007-09-01 may not appear yet. Historical indexing is in progress.

Interventions

DRUGRabipur

DRUGBCG VACCINE AJV por és oldószer szuszpenziós injekcióhoz BCG vakcina

DRUGfagyasztva szárított

Eligibility

Sex/Gender

All

Age

18 Years to 64 Years

Design outcomes

Primary

Measure	Time frame
Induction of mycobacterial growth control measured in vitro by MGIA (1 log reduction post vaccination compared to inoculum). Level of control in MGIA will be used as classifier to assess pre-vaccination functional status.	—

Secondary

Measure	Time frame
Imaging of dermal biopsies and correlation of relative subset distribution with functional mycobacterial growth control in MGIA. Frequencies of subsets in the dermis will be correlated with MGIA control capacity., Correlates of protection for both BCG (MGIA as best available correlate) and Rabipur (neutralizing antibodies) vaccinations will be compared and correlated., Correlation between cell frequencies and functional read outs prevaccination and at multiple post vaccination time points, Correlation of metabolic state to effector immune responses such as measured by MGIA and intracellular cytokine secretion.	—

Measure

Time frame

Imaging of dermal biopsies and correlation of relative subset distribution with functional mycobacterial growth control in MGIA. Frequencies of subsets in the dermis will be correlated with MGIA control capacity., Correlates of protection for both BCG (MGIA as best available correlate) and Rabipur (neutralizing antibodies) vaccinations will be compared and correlated., Correlation between cell frequencies and functional read outs prevaccination and at multiple post vaccination time points, Correlation of metabolic state to effector immune responses such as measured by MGIA and intracellular cytokine secretion.

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Countries

Netherlands

Outcome results

None listed