Dent 2 disease
Conditions
Brief summary
Improvement in the renal uptake of 99mTc-DMSA after 4 weeks of treatment (a p-value of ≤ 0.05 will be used to determine statistical significance).
Detailed description
Improvement of low-molecular weight proteinuria as assessed by changes urinary excretion of retinol-binding protein and beta-2 microglobulin after 4 weeks of treatment (a p-value of ≤ 0.05 will be used to determine statistical significance). − Improvement of the Fanconi syndrome as assessed by including 24-hour urine volume, urinary excretion of sodium, glucose, phosphate, amino acids, and changes in serum bicarbonate after 4 weeks of treatment (a p-value of ≤ 0.05 to determine statis sign)
Interventions
DRUGRENOCIS 1 mg kit for radiopharmaceutical preparation
Sponsors
Ospedale Pediatrico Bambino Gesu
Eligibility
Sex/Gender
Male
Age
18 Years to 64 Years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in the renal uptake of 99mTc-DMSA after 4 weeks of treatment (a p-value of ≤ 0.05 will be used to determine statistical significance). | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of low-molecular weight proteinuria as assessed by changes urinary excretion of retinol-binding protein and beta-2 microglobulin after 4 weeks of treatment (a p-value of ≤ 0.05 will be used to determine statistical significance). − Improvement of the Fanconi syndrome as assessed by including 24-hour urine volume, urinary excretion of sodium, glucose, phosphate, amino acids, and changes in serum bicarbonate after 4 weeks of treatment (a p-value of ≤ 0.05 to determine statis sign) | — |
Countries
Italy
Outcome results
None listed