RUBIKID - Dynamic 82-Rb positron emission tomography (PET) for the grading of KIDney carcinoma

Conditions

Kidney carcinoma

Brief summary

Intensity of 82-Rb uptake in the tumor calculated as the tumor to background ratio (ratio between SUV max in the tumor and the mean SUV in normal renal parenchyma).

Detailed description

Renal perfusion flow measured on 82-Rb-PET and the degree of neoangiogenesis in the tumor., Imaging biomarkers on 82-Rb-PET and the histological type of the tumor, Imaging biomarkers on 82-Rb-PET and tumor aggressiveness (ISUP grades) in patients with clear-cell renal adenocarcinomas., Rubidium uptake measured on 82-Rb-PET and degree of tumor vascularization measured on immuno-histology (CD34 and VEGF immunostaining)., Estimated residual renal function based on 82-Rb-PET and change of creatinine clearance between baseline and three months after surgery., Percentage of patients reclassified according to the gold-standard (ISUP grade of clear-cell renal adenocarcinomas on pathology)., The serious adverse events (SAE) related to 82-Rb

Related papers

No related papers found yet.

Interventions

DRUGRUBIDIUM CHLORIDE

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Intensity of 82-Rb uptake in the tumor calculated as the tumor to background ratio (ratio between SUV max in the tumor and the mean SUV in normal renal parenchyma).	—

Secondary

Measure	Time frame
Renal perfusion flow measured on 82-Rb-PET and the degree of neoangiogenesis in the tumor., Imaging biomarkers on 82-Rb-PET and the histological type of the tumor, Imaging biomarkers on 82-Rb-PET and tumor aggressiveness (ISUP grades) in patients with clear-cell renal adenocarcinomas., Rubidium uptake measured on 82-Rb-PET and degree of tumor vascularization measured on immuno-histology (CD34 and VEGF immunostaining)., Estimated residual renal function based on 82-Rb-PET and change of creatinine clearance between baseline and three months after surgery., Percentage of patients reclassified according to the gold-standard (ISUP grade of clear-cell renal adenocarcinomas on pathology)., The serious adverse events (SAE) related to 82-Rb	—

Measure

Time frame

Renal perfusion flow measured on 82-Rb-PET and the degree of neoangiogenesis in the tumor., Imaging biomarkers on 82-Rb-PET and the histological type of the tumor, Imaging biomarkers on 82-Rb-PET and tumor aggressiveness (ISUP grades) in patients with clear-cell renal adenocarcinomas., Rubidium uptake measured on 82-Rb-PET and degree of tumor vascularization measured on immuno-histology (CD34 and VEGF immunostaining)., Estimated residual renal function based on 82-Rb-PET and change of creatinine clearance between baseline and three months after surgery., Percentage of patients reclassified according to the gold-standard (ISUP grade of clear-cell renal adenocarcinomas on pathology)., The serious adverse events (SAE) related to 82-Rb

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Countries

France

Outcome results

None listed