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BIOLOGICAL STANDARDISATION OF ALLERGENIC EXTRACTS OF MITES (Dermatophagoides pteronyssinus, Dermatophagoides farinae, Blomia tropicalis and Lepidoglyphus destructor) TO DETERMINE BIOLOGICAL ACTIVITY IN HISTAMINE EQUIVALENT UNITS (HEP) IN SENSITIVISED PATIENTS.

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-513834-40-01
Acronym
DIA-STA04080912-0124
Enrollment
90
Registered
2024-08-29
Start date
2024-10-01
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Allergies

Brief summary

The area of the wheal (mm2) that occurs at the cutaneous level after the administration of the extracts in the prick test for the calculation of the primary endpoint

Detailed description

To determine the in vitro biological potency expressed as HEP (1 HEP = 10,000 biological units) of the concentration of the investigational product that elicits a wheal of a size equivalent to that produced by a solution of histamine dihydrochloride at 10 mg/ml., Safety assessment through descriptive analysis of adverse reactions that may occur during the course of the study.

Interventions

DRUGLepidoglyphus destructor skin-prick test
DRUGHistamine dihydrochloride skin-prick test
DRUGDermatophagoides pteronyssinus skin-prick test
DRUGDermatophagoides farinae skin-prick test
DRUGBlomia tropicalis skin-prick test

Sponsors

Diater Laboratorio De Diagnostico Y Aplicaciones Terapeuticas S.A.
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
18 Years to 64 Years

Design outcomes

Primary

MeasureTime frame
The area of the wheal (mm2) that occurs at the cutaneous level after the administration of the extracts in the prick test for the calculation of the primary endpoint

Secondary

MeasureTime frame
To determine the in vitro biological potency expressed as HEP (1 HEP = 10,000 biological units) of the concentration of the investigational product that elicits a wheal of a size equivalent to that produced by a solution of histamine dihydrochloride at 10 mg/ml., Safety assessment through descriptive analysis of adverse reactions that may occur during the course of the study.

Countries

Spain

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026