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Acute effects of SGLT2 inhibitor on kidney allograft oxygen tension: A randomized, double-blind, placebo controlled crossover trial

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-513765-40-00
Enrollment
8
Registered
2025-01-21
Start date
2025-03-27
Completion date
2025-09-09
Last updated
2025-01-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney transplant recipients

Brief summary

• Kidney allograft cortical and medullary oxygen tension, estimated by BOLD-MRI based renal T2* relaxation rate.

Detailed description

• Renal cortical and medullary perfusion ml/100 g/min, • Renal artery blood flow ml/min, • Blood glucose mmol/L, • Systolic blood pressure (SysBP) and diastolic blood pressure (DiaBP) mmHg, • Heart rate (HR), beats min-1

Interventions

DRUGPlacebo with no active substance and produces by the hospital pharmacy

Sponsors

Odense University Hospital
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
• Kidney allograft cortical and medullary oxygen tension, estimated by BOLD-MRI based renal T2* relaxation rate.

Secondary

MeasureTime frame
• Renal cortical and medullary perfusion ml/100 g/min, • Renal artery blood flow ml/min, • Blood glucose mmol/L, • Systolic blood pressure (SysBP) and diastolic blood pressure (DiaBP) mmHg, • Heart rate (HR), beats min-1

Countries

Denmark

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026