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Nivolumab during active surveillance after neoadjuvant chemoradiation for esophageal cancer: SANO-3 study

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-513635-24-00
Enrollment
74
Registered
2024-09-30
Start date
2022-09-29
Completion date
Unknown
Last updated
2024-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

oesophageal cancer

Brief summary

Disease-free survival (DFS), defined as the time elapsed between inclusion and locoregional or distant disease recurrence or death, whichever comes first.

Detailed description

Proportion of patients who develop locoregional disease recurrence, proportion of patients who develop distant metastases, Serious adverse events and grade 3-4 adverse events from the time of their first treatment with nivolumab according to the Common Terminology Criteria for Adverse Events (CTCAE version 5.0)

Interventions

DRUGOPDIVO 10 mg/mL concentrate for solution for infusion.

Sponsors

Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Disease-free survival (DFS), defined as the time elapsed between inclusion and locoregional or distant disease recurrence or death, whichever comes first.

Secondary

MeasureTime frame
Proportion of patients who develop locoregional disease recurrence, proportion of patients who develop distant metastases, Serious adverse events and grade 3-4 adverse events from the time of their first treatment with nivolumab according to the Common Terminology Criteria for Adverse Events (CTCAE version 5.0)

Countries

Netherlands

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026