Pheochromocytoma – endocrine adrenal tumor
Conditions
Brief summary
The number of detected pheochromocytoma lesions, proved by histology, with pathological [18F]mFBG uptake, defined as focal uptake above surrounding normal tissue, compared to number of lesions detected on protocollary conventional CT imaging prior to surgery.
Detailed description
1)Optimal time point of [18F]mFBG PET-CT imaging via comparison of SUV values at 1 and 2 hours on PET-CT imaging. 2) Correlation of [18F]mFBG PET findings with pathology and immunohistochemistry analysis of norepinephrine transporter. 3) Estimation of radiation dose of [18F]mFBG in normal tissues using dynamic PATLAK imaging 4) Safety analysis of [18F]mFBG administration on clinical symptoms will be evaluated by Adverse Events outcomes
Interventions
DRUG1-(3-(fluoro-18F)benzyl)guanidine ([18F]mFBG)
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of detected pheochromocytoma lesions, proved by histology, with pathological [18F]mFBG uptake, defined as focal uptake above surrounding normal tissue, compared to number of lesions detected on protocollary conventional CT imaging prior to surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Optimal time point of [18F]mFBG PET-CT imaging via comparison of SUV values at 1 and 2 hours on PET-CT imaging. 2) Correlation of [18F]mFBG PET findings with pathology and immunohistochemistry analysis of norepinephrine transporter. 3) Estimation of radiation dose of [18F]mFBG in normal tissues using dynamic PATLAK imaging 4) Safety analysis of [18F]mFBG administration on clinical symptoms will be evaluated by Adverse Events outcomes | — |
Countries
Netherlands
Outcome results
None listed