Disseminated cancer
Conditions
Brief summary
• Cumulative total intraoperative fluid (mL) administration at the end of the operation, including the amounts of crystalloids and blood products
Detailed description
• Cumulative total intraoperative fluid (mL/kg/h), • Postoperative fluid balance (mL), • Fluid balance at day 1 (mL), • Signs of fluid overload, assessed by Point-of-care ultrasound (POCUS, Appendix II) at day 0, 1 and 3., • Major complications as rated as Clavien Dindo score ≥2 up to postoperative day 30, • Abdominal complications up to day 30, • Pulmonary complications up to day 5, • Postoperative acute kidney injury as defined by the Kidney Disease Improving Global Outcomes definition (KDIGO) up to day 5, • Quality of recovery (QoR-15) at day 3, • Hospital and ICU length of stay, • 30-day mortality
Interventions
DRUGEmpressine 40 I.E./2ml
Sponsors
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • Cumulative total intraoperative fluid (mL) administration at the end of the operation, including the amounts of crystalloids and blood products | — |
Secondary
| Measure | Time frame |
|---|---|
| • Cumulative total intraoperative fluid (mL/kg/h), • Postoperative fluid balance (mL), • Fluid balance at day 1 (mL), • Signs of fluid overload, assessed by Point-of-care ultrasound (POCUS, Appendix II) at day 0, 1 and 3., • Major complications as rated as Clavien Dindo score ≥2 up to postoperative day 30, • Abdominal complications up to day 30, • Pulmonary complications up to day 5, • Postoperative acute kidney injury as defined by the Kidney Disease Improving Global Outcomes definition (KDIGO) up to day 5, • Quality of recovery (QoR-15) at day 3, • Hospital and ICU length of stay, • 30-day mortality | — |
Countries
Netherlands
Outcome results
None listed