Comparison of an inhaled sedation strategy with an intravenous sedation strategy in intensive care patients treated with invasive mechanical ventilation: INASED study

Conditions

Delirium

Brief summary

Occurrence (yes/no) of delirium in intensive care unit

Detailed description

ICU mortality, D28 mortality, - Length of stay in intensive care, - Number of days living without mechanical ventilation in intensive care at D28, - CAM-ICU scale (2 times/day), - The quality of sedation is defined by: compliance (yes/no) with the sedation target (sedation score set as the target when prescribing), - Need for additional medication to alleviate agitation (yes/no, and if yes neuroleptic, benzodiazepine, dexmedetomidine), - Need for additional physical restraint to alleviate a state of agitation (yes/no), - Number of accidental removals by the patient of intubation tubes, vascular access tubes, nasogastric tubes and urinary catheters, based on the number of days in intensive care., - Number of self- or hetero-aggressive acts per number of days in intensive care, - Average hospital costs per patient, - Daily and cumulative dose of sedative, - Cognitive consequences will be assessed. Calculation of CDR and IQCODE scores. Cognitive, psychological and quality of life assessment at 3 and 12 months.

Related papers

No related papers found yet.

Interventions

DRUGISOFLURANE BELAMONT

DRUGliquide pour inhalation par vapeur

DRUGPropofol Baxter 10 mg/mL Emulsion zur Injektion/Infusion

DRUGSUFENTANIL

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Occurrence (yes/no) of delirium in intensive care unit	—

Secondary

Measure	Time frame
ICU mortality, D28 mortality, - Length of stay in intensive care, - Number of days living without mechanical ventilation in intensive care at D28, - CAM-ICU scale (2 times/day), - The quality of sedation is defined by: compliance (yes/no) with the sedation target (sedation score set as the target when prescribing), - Need for additional medication to alleviate agitation (yes/no, and if yes neuroleptic, benzodiazepine, dexmedetomidine), - Need for additional physical restraint to alleviate a state of agitation (yes/no), - Number of accidental removals by the patient of intubation tubes, vascular access tubes, nasogastric tubes and urinary catheters, based on the number of days in intensive care., - Number of self- or hetero-aggressive acts per number of days in intensive care, - Average hospital costs per patient, - Daily and cumulative dose of sedative, - Cognitive consequences will be assessed. Calculation of CDR and IQCODE scores. Cognitive, psychological and quality of life assessme	—

Measure

Time frame

ICU mortality, D28 mortality, - Length of stay in intensive care, - Number of days living without mechanical ventilation in intensive care at D28, - CAM-ICU scale (2 times/day), - The quality of sedation is defined by: compliance (yes/no) with the sedation target (sedation score set as the target when prescribing), - Need for additional medication to alleviate agitation (yes/no, and if yes neuroleptic, benzodiazepine, dexmedetomidine), - Need for additional physical restraint to alleviate a state of agitation (yes/no), - Number of accidental removals by the patient of intubation tubes, vascular access tubes, nasogastric tubes and urinary catheters, based on the number of days in intensive care., - Number of self- or hetero-aggressive acts per number of days in intensive care, - Average hospital costs per patient, - Daily and cumulative dose of sedative, - Cognitive consequences will be assessed. Calculation of CDR and IQCODE scores. Cognitive, psychological and quality of life assessme

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Countries

France

Outcome results

None listed