Does Colchicine Reduce Progression of Aortic Valve Stenosis? Colchicine and Inflammation in Aortic Stenosis (CHIANTI): A placebo-controlled, double-blind, multicenter randomized trial.

Status

Not yet recruiting

Phases

Phase 3

Study type

Interventional

Source

EU CTIS

Registry ID

CTIS2024-513486-39-00

Enrollment

150

Registered

2024-12-06

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Valve Calcification, Aortic Valve Disease, Aortic Valve Stenosis, Calcification, Cardiovascular Diseases, Inflammation

Brief summary

The change in aortic valve calcium score measured by computed tomography (Agatston Units) at 24 months relative to baseline.

Detailed description

The change in 18F-NaF uptake of the aortic valve on positron emission tomography at 24 months relative to baseline., The change in peak aortic jet velocity (m/s) measured by echocardiography at 24 months relative to baseline.

Interventions

DRUGPlacebo Colchicine 0.5 mg tablets

DRUGColchicine Tiofarma 0

DRUG5 mg

DRUGtabletten

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
The change in aortic valve calcium score measured by computed tomography (Agatston Units) at 24 months relative to baseline.	—

Secondary

Measure	Time frame
The change in 18F-NaF uptake of the aortic valve on positron emission tomography at 24 months relative to baseline., The change in peak aortic jet velocity (m/s) measured by echocardiography at 24 months relative to baseline.	—

Countries

Netherlands

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026