Effects of Digoxin in Modern Heart Failure Treatment

Conditions

Heart Failure

Brief summary

Peak oxygen consumption measured by Cardiopulmonary Exercise Test at 24 weeks., Global Work Index measured by Echocardiography at 24 weeks.

Detailed description

Composite of death, hospitalizations, and ventricular arrhythmia from baseline to 24 weeks., KCCQ-12 Score at 24 weeks., Changes in analytical parameters at 24 weeks: NTproBNP, Glomerular filtration rate, urine ratio of albumin/creatinine, C-reactive protein, aldosterone and renin plasma values., Cardiopulmonary exercise test parameters at 24 weeks: Peak oxygenconsumption (percentage of predicted), Oxygen consumption at anaerobic threshold, VE/VCO2 slope, Duration of exercise, Optimal point of ventilation., ECG parameters at 24 weeks: QRS interval., Echocardiography parameters at 24 weeks: Global Constructive Work, Global Wasted Work, Global Work Efficiency, Global Longitudinal Strain, Left Ventricular Ejection Fraction, Right ventricular fractional area change, Free-wall right ventricle longitudinal strain, Left ventricle end-diastolic volume, Left Atrial Reservoir Strain, Mechanical dispersion, E/e´

Related papers

No related papers found yet.

Papers published before 2008-02-04 may not appear yet. Historical indexing is in progress.

Interventions

DRUGNorit Carbomix 50 g granulado para suspensão oral

DRUGLanoxin MD 0

DRUG125 mg comprimido

DRUGDigiFab® (referred to as DIGIFAB) 40 mg/vial digoxin immune Fab

DRUGPowder for solution for infusion

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Peak oxygen consumption measured by Cardiopulmonary Exercise Test at 24 weeks., Global Work Index measured by Echocardiography at 24 weeks.	—

Secondary

Measure	Time frame
Composite of death, hospitalizations, and ventricular arrhythmia from baseline to 24 weeks., KCCQ-12 Score at 24 weeks., Changes in analytical parameters at 24 weeks: NTproBNP, Glomerular filtration rate, urine ratio of albumin/creatinine, C-reactive protein, aldosterone and renin plasma values., Cardiopulmonary exercise test parameters at 24 weeks: Peak oxygenconsumption (percentage of predicted), Oxygen consumption at anaerobic threshold, VE/VCO2 slope, Duration of exercise, Optimal point of ventilation., ECG parameters at 24 weeks: QRS interval., Echocardiography parameters at 24 weeks: Global Constructive Work, Global Wasted Work, Global Work Efficiency, Global Longitudinal Strain, Left Ventricular Ejection Fraction, Right ventricular fractional area change, Free-wall right ventricle longitudinal strain, Left ventricle end-diastolic volume, Left Atrial Reservoir Strain, Mechanical dispersion, E/e´	—

Measure

Time frame

Composite of death, hospitalizations, and ventricular arrhythmia from baseline to 24 weeks., KCCQ-12 Score at 24 weeks., Changes in analytical parameters at 24 weeks: NTproBNP, Glomerular filtration rate, urine ratio of albumin/creatinine, C-reactive protein, aldosterone and renin plasma values., Cardiopulmonary exercise test parameters at 24 weeks: Peak oxygenconsumption (percentage of predicted), Oxygen consumption at anaerobic threshold, VE/VCO2 slope, Duration of exercise, Optimal point of ventilation., ECG parameters at 24 weeks: QRS interval., Echocardiography parameters at 24 weeks: Global Constructive Work, Global Wasted Work, Global Work Efficiency, Global Longitudinal Strain, Left Ventricular Ejection Fraction, Right ventricular fractional area change, Free-wall right ventricle longitudinal strain, Left ventricle end-diastolic volume, Left Atrial Reservoir Strain, Mechanical dispersion, E/e´

—

Countries

Portugal

Outcome results

None listed