Autosomal Dominant Polycystic Kidney Disease
Conditions
Brief summary
The three primary outcomes of this study are the differences in pulse wave velocity (PWV) in high salt versus placebo group, and before versus after amiloride treatment in both groups.
Detailed description
Ambulatory (24-hours) blood pressure measurements, Serum markers of inflammation, Other relevant serum markers for inflammation and endothelial dysfunction, 23Na-MRI scans measuring interstitial sodium accumulation in a subgroup of patients, Salt tasting sensitivity
Interventions
DRUGPlacebo used in this trial is a foodgrade
DRUGredried potato starch. It is a white powder with bland taste and free from objectionable odours. Insoluble in water with a temperature below 50 °C and most organic solvents
DRUGsolution is slightly hazy. The product is intended for use in food.
DRUGPOTATO STARCH
DRUGSODIUM CHLORIDE
DRUGAMILORIDE
Sponsors
Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The three primary outcomes of this study are the differences in pulse wave velocity (PWV) in high salt versus placebo group, and before versus after amiloride treatment in both groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ambulatory (24-hours) blood pressure measurements, Serum markers of inflammation, Other relevant serum markers for inflammation and endothelial dysfunction, 23Na-MRI scans measuring interstitial sodium accumulation in a subgroup of patients, Salt tasting sensitivity | — |
Countries
Netherlands
Outcome results
None listed