neurological disorders
Conditions
Brief summary
Dual-task costs (DTC): calculated as the difference between the scores of the dual-task and single-task performances and measured as reaction time (ms) in the cognitive task and motor pedaling speed (ms) in the motor task after donepezil or placebo administration, respectively, at V1 and 2
Detailed description
Neuronal activity: measured after donepezil or placebo administration, respectively, by fMRI during task performance at visit 1 and 2, Relative cognitive and motor performances in other neuropsychological tests: 1. measured by reaction times (ms) and % correct responses in the sub-tests of TAP-M test battery and 2. measured by time (s) conducting the TUG-test variant, both after donepezil or placebo administration, respectively, at V1 and 2
Interventions
DRUGDonepezilhydrochlorid Heumann 5 mg Filmtabletten
DRUGPlacebo to match Donepezil
Sponsors
Carl Von Ossietzky Universitaet Oldenburg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dual-task costs (DTC): calculated as the difference between the scores of the dual-task and single-task performances and measured as reaction time (ms) in the cognitive task and motor pedaling speed (ms) in the motor task after donepezil or placebo administration, respectively, at V1 and 2 | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuronal activity: measured after donepezil or placebo administration, respectively, by fMRI during task performance at visit 1 and 2, Relative cognitive and motor performances in other neuropsychological tests: 1. measured by reaction times (ms) and % correct responses in the sub-tests of TAP-M test battery and 2. measured by time (s) conducting the TUG-test variant, both after donepezil or placebo administration, respectively, at V1 and 2 | — |
Countries
Germany
Outcome results
None listed