Evaluation of the CKD-Epi score to identify a glomerular filtration threshold predictive of morphine failure at usual dosage, using a reference method for assessing renal function: iohexol clearance. All other aspects of the protocol are part of standard care practice.
Conditions
Brief summary
The primary endpoint was the area under the ROC curve for prediction of therapeutic failure by GFR according to CKD Epi. Therapeutic failure is defined by a percentage of relief assessed by EVN (numerical verbal scale) not reaching 30% in 24h (Darbari, 2017).
Detailed description
Clearance of morphine and its metabolites M3G and M6G, Total morphine dose administered over 24 hours and 7 days, Evolution of pain by EVN and EVA (delta over 24h) and PGIC scale at 24h follow-up, Patient-controlled analgesia (PCA) regimen and other coadministered analgesics, Morphine side effects, including impaired alertness, bradypnea, hypercapnia, pruritus, constipation, bloating, nausea, vomiting, acute urinary retention, Correlation between GFR estimated by CKD Epi in basal st
Interventions
DRUGIohexol 300 mg I/ml solution for injection
DRUGMORPHINE (CHLORHYDRATE) RENAUDIN 1 mg/ml
DRUGsolution injectable
Sponsors
Centre Hospitalier Regional Universitaire De Tours
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint was the area under the ROC curve for prediction of therapeutic failure by GFR according to CKD Epi. Therapeutic failure is defined by a percentage of relief assessed by EVN (numerical verbal scale) not reaching 30% in 24h (Darbari, 2017). | — |
Secondary
| Measure | Time frame |
|---|---|
| Clearance of morphine and its metabolites M3G and M6G, Total morphine dose administered over 24 hours and 7 days, Evolution of pain by EVN and EVA (delta over 24h) and PGIC scale at 24h follow-up, Patient-controlled analgesia (PCA) regimen and other coadministered analgesics, Morphine side effects, including impaired alertness, bradypnea, hypercapnia, pruritus, constipation, bloating, nausea, vomiting, acute urinary retention, Correlation between GFR estimated by CKD Epi in basal st | — |
Countries
France
Outcome results
None listed