Use of MULTIplex PCR, procalcitonin and the appearance of sputum to reduce the duration of antibiotic therapy during severe COPD EXAcerbation: a trial controlled, randomized, open, in parallel groups, multicenter (MULTI-EXA)

EA-COPD (with mechanical ventilation, invasive or non-invasive, or high-flow nasal oxygen therapy).

Number of days alive without antibiotics on D28.

Number of days with antibiotics in patients alive on D28, Number of days with broad-spectrum antibiotics in patients alive on D28, Incidence rate of nosocomial pneumonia on day 28;, Incidence rate of colonization/infection with multi-resistant bacteria on day 28;, Duration of stay in ICU/ICU at D28,, Length of hospital stay on D28;, Number of days alive without mechanical ventilation on D28, - Incidence rate of hospital-acquired pneumonia (including ventilator-acquired pneumonia) on day 28;, Mortality in ICU/ICU and in hospital (on day 28 and day 90);, - Number of additional EA-COPD(s) (requiring hospitalization and/or initiation of systemic corticosteroid therapy and/or antibiotic therapy) after the index EA-COPD (at D90);, Time between the index EA-COPD and the next EA-COPD (EA-COPD requiring hospitalization and/or initiation of systemic corticosteroid therapy and/or antibiotic therapy) (at D90);, CAT questionnaire (COPD Assessment Test) (at D90).

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