Oesophageal adenocarcinoma
Conditions
Brief summary
Metabolic switch in macrophages measured by M2 to M1 macrophage polarization within the tumour immune microenvironment and the number of CD8 intratumoral T-cell infiltration determined with single cell mRNA sequencing.
Detailed description
Measure changes in T cell infiltration and the CD3:CD163 ratio within the spatial context by multicolor immunohistochemistry (mIHC)., Detect metabolic changes in macrophages and T cells in the tumour immune microenvi-ronment by SCENITH flow cytometry analysis., Pathological response according to pTNM stage and Mandard criteria, Adverse events based on Common Toxicity Criteria for Adverse Events (CTCAE)., Progression free survival, Overall survival
Interventions
DRUGMetformin Aurobindo 500 mg film-coated tablets
Sponsors
Amsterdam UMC Stichting
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolic switch in macrophages measured by M2 to M1 macrophage polarization within the tumour immune microenvironment and the number of CD8 intratumoral T-cell infiltration determined with single cell mRNA sequencing. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measure changes in T cell infiltration and the CD3:CD163 ratio within the spatial context by multicolor immunohistochemistry (mIHC)., Detect metabolic changes in macrophages and T cells in the tumour immune microenvi-ronment by SCENITH flow cytometry analysis., Pathological response according to pTNM stage and Mandard criteria, Adverse events based on Common Toxicity Criteria for Adverse Events (CTCAE)., Progression free survival, Overall survival | — |
Countries
Netherlands
Outcome results
None listed