dTap booster vaccination of health care workers (HC dTap)

Conditions

Diphtheria, tetanus, pertussis (wooping cough)

Brief summary

The percentage of study participants with PT-specific IgG antibody geometric mean concentration (GMC) ≥5 IU/mL 0-7 days pre-vaccination.

Detailed description

PT-specific IgG antibody geometric mean concentration (GMC) 28 days after vaccination., The difference in FHA, PRN, and Fimbriae 2/3 IgG antibody GMCs pre- and 28 days post-vaccination., Pertussis antigen-specific plasma B-cell frequencies pre- and 28 days post-vaccination measured by ELISpot., Pertussis antigen-specific memory B-cell frequencies pre- and 28 days post-vaccination measured by ELISpot., Pertussis antigen-specific T-cell responses determined by cytokine analysis either from pertussis antigen stimulated whole blood samples/PBMC’s and/or supernatants., Assays measuring pertussis specific functional immunity include: PT neutralization; PT epitope specific antibodies; avidity; adherence inhibition; bactericidal activity; bacterial opsonization and phagocytosis undertaken on serum samples taken pre- and 28 days post-vaccination., Tetanus- and diphtheria toxoid-specific IgG antibody GMC measured by ELISA pre- and 28 days post-vaccination.

Related papers

No related papers found yet.

Interventions

DRUGTriaxis injektioneste

DRUGsuspensio

DRUGesitäytetty ruisku. Kurkkumätä

DRUGjäykkäkouristus ja hinkuyskä (soluton

DRUGkomponentti) -rokote (adsorboitu

DRUGvähennetty antigeeni(en) pitoisuus)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
The percentage of study participants with PT-specific IgG antibody geometric mean concentration (GMC) ≥5 IU/mL 0-7 days pre-vaccination.	—

Secondary

Measure	Time frame
PT-specific IgG antibody geometric mean concentration (GMC) 28 days after vaccination., The difference in FHA, PRN, and Fimbriae 2/3 IgG antibody GMCs pre- and 28 days post-vaccination., Pertussis antigen-specific plasma B-cell frequencies pre- and 28 days post-vaccination measured by ELISpot., Pertussis antigen-specific memory B-cell frequencies pre- and 28 days post-vaccination measured by ELISpot., Pertussis antigen-specific T-cell responses determined by cytokine analysis either from pertussis antigen stimulated whole blood samples/PBMC’s and/or supernatants., Assays measuring pertussis specific functional immunity include: PT neutralization; PT epitope specific antibodies; avidity; adherence inhibition; bactericidal activity; bacterial opsonization and phagocytosis undertaken on serum samples taken pre- and 28 days post-vaccination., Tetanus- and diphtheria toxoid-specific IgG antibody GMC measured by ELISA pre- and 28 days post-vaccination.	—

Measure

Time frame

PT-specific IgG antibody geometric mean concentration (GMC) 28 days after vaccination., The difference in FHA, PRN, and Fimbriae 2/3 IgG antibody GMCs pre- and 28 days post-vaccination., Pertussis antigen-specific plasma B-cell frequencies pre- and 28 days post-vaccination measured by ELISpot., Pertussis antigen-specific memory B-cell frequencies pre- and 28 days post-vaccination measured by ELISpot., Pertussis antigen-specific T-cell responses determined by cytokine analysis either from pertussis antigen stimulated whole blood samples/PBMC’s and/or supernatants., Assays measuring pertussis specific functional immunity include: PT neutralization; PT epitope specific antibodies; avidity; adherence inhibition; bactericidal activity; bacterial opsonization and phagocytosis undertaken on serum samples taken pre- and 28 days post-vaccination., Tetanus- and diphtheria toxoid-specific IgG antibody GMC measured by ELISA pre- and 28 days post-vaccination.

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Countries

Finland

Outcome results

None listed