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General anesthesia versus sedation with high-flow nasal cannula for the endovascular treatment of acute ischemic stroke. GHIFTS Study (General anesthesia vs High Flow nasal cannula for Thrombectomy on Stroke)

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2024-510752-12-00
Acronym
GHIFTS
Enrollment
116
Registered
2024-08-14
Start date
2024-11-13
Completion date
Unknown
Last updated
2024-09-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute ischemic stroke

Brief summary

Time between arrival at the hospital door and arterial recanalization (in minutes). This time has been shown to be sensitive to the type of anesthetic procedure used in the different meta-analyses published and, in addition to including the time of the intervention, which may also be influenced by the anesthetic technique, it is less affected by other factors than other times collected for the assessment of stroke treatment, such as the time from onset of the clinic to recanalization.

Detailed description

NIHSS scale at 24 hours and the modified Rankin scale (mRS) 90 days after stroke., Door time - arterial puncture: minutes. Arterial puncture time - recanalization: minutes, Degree of arterial recanalization, according to the mTICI scale (modified Thrombolysis in Cerebral Infarction Scale): 0-3, Incidence of complications during the intervention in both groups (arterial perforation, dissection, embolisms to new territories, complications at the point of arterial puncture, arterial hypertension or hypotension, arrhythmias, hypoxemia, and bronchial aspiration) as well as after the procedure (cerebral hemorrhage, hypertension or hypotension, arrhythmias, hypoxemia or pneumonia). Their presence will be assessed after 24 hours, and upon discharge from hospital.

Interventions

DRUGLidocaína B. Braun 10 mg/ml solución inyectable
DRUGEsmeron 10 mg/ml solución inyectable y para perfusión
DRUGAire medicinal sintético Carburos Metálicos
DRUG22% v/v
DRUGgas medicinal
DRUGcomprimido

Sponsors

Hospital Universitario La Paz
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Time between arrival at the hospital door and arterial recanalization (in minutes). This time has been shown to be sensitive to the type of anesthetic procedure used in the different meta-analyses published and, in addition to including the time of the intervention, which may also be influenced by the anesthetic technique, it is less affected by other factors than other times collected for the assessment of stroke treatment, such as the time from onset of the clinic to recanalization.

Secondary

MeasureTime frame
NIHSS scale at 24 hours and the modified Rankin scale (mRS) 90 days after stroke., Door time - arterial puncture: minutes. Arterial puncture time - recanalization: minutes, Degree of arterial recanalization, according to the mTICI scale (modified Thrombolysis in Cerebral Infarction Scale): 0-3, Incidence of complications during the intervention in both groups (arterial perforation, dissection, embolisms to new territories, complications at the point of arterial puncture, arterial hypertension or hypotension, arrhythmias, hypoxemia, and bronchial aspiration) as well as after the procedure (cerebral hemorrhage, hypertension or hypotension, arrhythmias, hypoxemia or pneumonia). Their presence will be assessed after 24 hours, and upon discharge from hospital.

Countries

Spain

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026