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TAZEMETOSTAT ROLLOVER STUDY (TRUST): AN OPEN-LABEL, ROLLOVER STUDY

Status
Completed
Phases
Phase 1Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2023-510553-41-00
Acronym
EZH-501
Enrollment
40
Registered
2024-05-22
Start date
2016-08-29
Completion date
2025-09-26
Last updated
2025-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subjects will receive tazemetostat as dictated in their antecedent study.

Brief summary

Number of subjects with adverse events related to study drug, as a measure of safety and tolerability of tazemetostat, Number of subjects with adverse events, as a measure of safety and tolerability of tazemetostat, Extent of exposure to tazemetostat

Detailed description

The OS of subjects receiving tazemetostat, defined as the interval of time between the date of the first dose of tazemetostat and the date of death due to any cause

Interventions

None listed

Sponsors

Epizyme Inc.
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
0 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Number of subjects with adverse events related to study drug, as a measure of safety and tolerability of tazemetostat, Number of subjects with adverse events, as a measure of safety and tolerability of tazemetostat, Extent of exposure to tazemetostat

Secondary

MeasureTime frame
The OS of subjects receiving tazemetostat, defined as the interval of time between the date of the first dose of tazemetostat and the date of death due to any cause

Countries

France, Poland

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026