RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTIPLE ASCENDING DOSE STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF IA-14069 IN HEALTHY SUBJECTS, WITH AN EXTENSION TO EXPLORE ANY DRUG-DRUG INTERACTION POTENTIAL WITH METHOTREXATE (PART 1), AND IN PATIENTS WITH RHEUMATOID ARTHRITIS, WITH PRELIMINARY ASSESSMENT OF EFFICACY IN PATIENTS (PART 2)