Zoledronate Early to Hip Fractures Patients – safe and effective? A Randomized controlled double-blinded treatment strategy trial on Zoledronate in hip fracture patients: The ZEBRA trial

Conditions

Hip fracture

Brief summary

Difference between the two groups in proportion of patients having P1NP>35µg/L 12 months after treatment with zoledronate

Detailed description

Grade of early mobilization measured by CAS score in hospital/at discharge from hospital, Number of patients with delirium assessed by 4AT in hospital, Difference between the two groups in proportion of patients having CTX>0.28µg/L 12 months after treatment with zoledronate, Change in BMD 12 months after treatment with zoledronate, Grade of mobilization and rehabilitation 3 months after fracture measured by TUG test, Number of patients with fever (T> 38’C) in hospital, Number of patients treated with antibiotics in hospital, Time to discharge from hospital after admission and after the hip fracture surgery, Time to and number of readmissions to hospital (any department), Time to and number of new fractures, Time to and number of deaths

Related papers

No related papers found yet.

Interventions

DRUGZOLEDRONIC ACID

DRUGELECTROLYTES

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Difference between the two groups in proportion of patients having P1NP>35µg/L 12 months after treatment with zoledronate	—

Secondary

Measure	Time frame
Grade of early mobilization measured by CAS score in hospital/at discharge from hospital, Number of patients with delirium assessed by 4AT in hospital, Difference between the two groups in proportion of patients having CTX>0.28µg/L 12 months after treatment with zoledronate, Change in BMD 12 months after treatment with zoledronate, Grade of mobilization and rehabilitation 3 months after fracture measured by TUG test, Number of patients with fever (T> 38’C) in hospital, Number of patients treated with antibiotics in hospital, Time to discharge from hospital after admission and after the hip fracture surgery, Time to and number of readmissions to hospital (any department), Time to and number of new fractures, Time to and number of deaths	—

Measure

Time frame

Grade of early mobilization measured by CAS score in hospital/at discharge from hospital, Number of patients with delirium assessed by 4AT in hospital, Difference between the two groups in proportion of patients having CTX>0.28µg/L 12 months after treatment with zoledronate, Change in BMD 12 months after treatment with zoledronate, Grade of mobilization and rehabilitation 3 months after fracture measured by TUG test, Number of patients with fever (T> 38’C) in hospital, Number of patients treated with antibiotics in hospital, Time to discharge from hospital after admission and after the hip fracture surgery, Time to and number of readmissions to hospital (any department), Time to and number of new fractures, Time to and number of deaths

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Countries

Norway

Outcome results

None listed