acute ischemic stroke
Conditions
Brief summary
Early neurological improvement, defined as a reduction of ≥8 points on the National Institutes of Health Stroke Scale (NIHSS), or NIHSS of 0-1 at 24 hours ± 12.
Detailed description
Percentage change in NIHSS from baseline to 24 h ± 12 h., Percent change in infarct volume at 24 h ± 12 hours., Proportion of patients: - obtaining a good functional outcome (mRS 0-2) at day 90 (+/- 2weeks); obtaining an excellent functional outcome (mRS 0-1) at day 90 (+/- 2 weeks); mRS category at day 90 (+/- 2 weeks)., Occurrence of sICH on CT/MRI within 36 hours post IVT causally related to an increase of 4 points or more on the NIHSS., Any ICH on CT/MR within 36 hours post IVT., Occurrence of death within 90 days.
Interventions
DRUGRIVAROXABAN
DRUGAPIXABAN
DRUGTENECTEPLASE
DRUGALTEPLASE
DRUGEDOXABAN
Sponsors
Oslo University Hospital HF
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Early neurological improvement, defined as a reduction of ≥8 points on the National Institutes of Health Stroke Scale (NIHSS), or NIHSS of 0-1 at 24 hours ± 12. | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage change in NIHSS from baseline to 24 h ± 12 h., Percent change in infarct volume at 24 h ± 12 hours., Proportion of patients: - obtaining a good functional outcome (mRS 0-2) at day 90 (+/- 2weeks); obtaining an excellent functional outcome (mRS 0-1) at day 90 (+/- 2 weeks); mRS category at day 90 (+/- 2 weeks)., Occurrence of sICH on CT/MRI within 36 hours post IVT causally related to an increase of 4 points or more on the NIHSS., Any ICH on CT/MR within 36 hours post IVT., Occurrence of death within 90 days. | — |
Countries
Norway
Outcome results
None listed