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Repurposing Everolimus to enhance musculoskeletal Vitality and Ageing in The Elderly (RENOVATE)

Status
Not yet recruiting
Phases
Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2023-509838-19-00
Enrollment
120
Registered
2024-03-14
Start date
Unknown
Completion date
Unknown
Last updated
2024-03-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General healthy elderly with stable medical conditions

Brief summary

Changes in serum bone formation marker P1NP

Detailed description

Changes in serum bone resorption marker CTX, Changes in areal BMD at the lumbar spine, total hip and femoral neck measured by DXA scanning, Changes in volumetric BMD, bone microstructures and estimated strength at distal tibia and radius (HRpQT), Changes in muscle function, power and strength for upper and lower extremities will be assessed using a standard hydraulic hand dynamometer, the 30-second sit-to-stand test (RSS), respectively and gait speed., Changes in health-related quality of life assessment (SF-12 questionnaire)

Interventions

DRUGTetracycline Capsules 250 mg
DRUGPLACEBO

Sponsors

Odense University Hospital
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Changes in serum bone formation marker P1NP

Secondary

MeasureTime frame
Changes in serum bone resorption marker CTX, Changes in areal BMD at the lumbar spine, total hip and femoral neck measured by DXA scanning, Changes in volumetric BMD, bone microstructures and estimated strength at distal tibia and radius (HRpQT), Changes in muscle function, power and strength for upper and lower extremities will be assessed using a standard hydraulic hand dynamometer, the 30-second sit-to-stand test (RSS), respectively and gait speed., Changes in health-related quality of life assessment (SF-12 questionnaire)

Countries

Denmark

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026