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EVOLVE-MI: A Pragmatic Randomized Multicenter Trial of EVOLocumab Administered Very Early to Reduce the Risk of Cardiovascular Events in Patients Hospitalized With Acute Myocardial Infarction

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2023-509268-26-00
Acronym
20190184
Enrollment
700
Registered
2024-04-04
Start date
2024-01-08
Completion date
Unknown
Last updated
2024-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dyslipidemia

Brief summary

Total (first and subsequent) composite of myocardial infarction, ischemic stroke, any arterial revascularization procedure, and all-cause death.

Detailed description

Percent LDL-C change from baseline to 12 weeks and 52 week in a subset of approximately 300 selected subjects., Total (first and subsequent) composite of myocardial infarction, ischemic stroke, any arterial revascularization procedure, and cardiovascular death., Time to the first occurrence of the composite of myocardial infarction, ischemic stroke, revascularization procedure, and all-cause death., Total myocardial infarctions, Total arterial revascularization procedures, Total ischemia-driven coronary revascularization procedures, Total ischemic strokes, Cardiovascular death, All-cause death

Interventions

DRUGEVOLOCUMAB

Sponsors

Amgen Inc.
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Total (first and subsequent) composite of myocardial infarction, ischemic stroke, any arterial revascularization procedure, and all-cause death.

Secondary

MeasureTime frame
Percent LDL-C change from baseline to 12 weeks and 52 week in a subset of approximately 300 selected subjects., Total (first and subsequent) composite of myocardial infarction, ischemic stroke, any arterial revascularization procedure, and cardiovascular death., Time to the first occurrence of the composite of myocardial infarction, ischemic stroke, revascularization procedure, and all-cause death., Total myocardial infarctions, Total arterial revascularization procedures, Total ischemia-driven coronary revascularization procedures, Total ischemic strokes, Cardiovascular death, All-cause death

Countries

Sweden

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026