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Optimizing metformin use in polycystic ovary syndrome - A randomized controlled trial

Status
Not yet recruiting
Phases
Phase 4
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2023-509259-15-01
Enrollment
184
Registered
2025-02-06
Start date
Unknown
Completion date
Unknown
Last updated
2025-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovary syndrome

Brief summary

Anthropometrics (weight), Androgenicity (hirsutism and testosterone), Metabolic (HOMA-IR), Gastrointestinal side-effects (nausea, vomiting, abdominal pain), Polycystic ovary morphology: AMH

Detailed description

Androgenicity: FAI, SHBG, DHEAS, androstenedione, free testosterone, acne and alopecia, Menstrual cyclicity (questionnaire where asking how long the two previous cycles were (days), Quality of life and weight stigma: anxiety, weight stigma, Metabolic: fasting glucose, fasting insulin, HbA1C, lipids, CRP, ALAT, GGT, OGTT, FLI, Matsuda Index, TyG index, Polycystic ovary morphology: ultrasound (follicle number per ovary, ovarian volume), Anthropometric (BMI, waist-hip-ratio, WC, BAI, body composition, bloodpressure, pulse)

Interventions

DRUGMETFORMIN
DRUGMETFORMIN HYDROCHLORIDE

Sponsors

HUS-yhtymae
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to 64 Years

Design outcomes

Primary

MeasureTime frame
Anthropometrics (weight), Androgenicity (hirsutism and testosterone), Metabolic (HOMA-IR), Gastrointestinal side-effects (nausea, vomiting, abdominal pain), Polycystic ovary morphology: AMH

Secondary

MeasureTime frame
Androgenicity: FAI, SHBG, DHEAS, androstenedione, free testosterone, acne and alopecia, Menstrual cyclicity (questionnaire where asking how long the two previous cycles were (days), Quality of life and weight stigma: anxiety, weight stigma, Metabolic: fasting glucose, fasting insulin, HbA1C, lipids, CRP, ALAT, GGT, OGTT, FLI, Matsuda Index, TyG index, Polycystic ovary morphology: ultrasound (follicle number per ovary, ovarian volume), Anthropometric (BMI, waist-hip-ratio, WC, BAI, body composition, bloodpressure, pulse)

Countries

Finland

Outcome results

None listed

Source: EU CTIS · Data processed: Mar 14, 2026