Type 1 Diabetes
Conditions
Brief summary
The primary endpoint is defined as the proportion of participants who achieve the lowest AUC glucose with ultra-rapid-acting insulin analog in the tertiles with the fastest vs. the slowest gastric emptying (t1/2), compared to the proportion of participants who achieve the lowest AUCglucose with regular insulin in the tertiles with the slowest vs. the fastest gastric emptying (t1/2)
Detailed description
Comparison of meal-associated excursions of ROS (Nitrotyrosine, oxidized Low-Density Lipoproteins (oxLDL)), Comparison of meal-associated excursions of plasma glucose and triglyceride concentrations, Comparison of gastric emptying rates (t1/2), Coefficient of variation of gastric emptying variability (t1/2), Correlation of AUCglucose with gastric emptying (t1/2) considering the choice of insulin preparation (ultra-rapid-acting insulin, rapid-acting insulin, and regular insulin)
Interventions
DRUGHuminsulin® Normal 100 100 I.E./ml Injektionslösung in Durchstechflasche
Sponsors
Katholisches Klinikum Bochum gGmbH
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is defined as the proportion of participants who achieve the lowest AUC glucose with ultra-rapid-acting insulin analog in the tertiles with the fastest vs. the slowest gastric emptying (t1/2), compared to the proportion of participants who achieve the lowest AUCglucose with regular insulin in the tertiles with the slowest vs. the fastest gastric emptying (t1/2) | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of meal-associated excursions of ROS (Nitrotyrosine, oxidized Low-Density Lipoproteins (oxLDL)), Comparison of meal-associated excursions of plasma glucose and triglyceride concentrations, Comparison of gastric emptying rates (t1/2), Coefficient of variation of gastric emptying variability (t1/2), Correlation of AUCglucose with gastric emptying (t1/2) considering the choice of insulin preparation (ultra-rapid-acting insulin, rapid-acting insulin, and regular insulin) | — |
Countries
Germany
Outcome results
None listed