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A randomized comparison of one controlled ovarian stimulation with corifollitropin alfa (CFA) versus up to three modified natural cycles (MNC) in expected and established poor responders

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2023-509094-23-00
Acronym
MONACO
Enrollment
300
Registered
2024-06-27
Start date
2022-07-15
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subfertility

Brief summary

the probability of having at least one good quality blastocyst after ART (on the day of embryo transfer) (binary endpoint).

Detailed description

the relative number of blastocyts after ART (on the day of embryo transfer), relative to the number of oocytes (rate), the probability of having at least one blastocyst of good quality after ART (on the day of embryo transfer) (binary endpoint), the probability of having an ongoing pregnancy which is defined as 6 to 8 weeks gestational age (binary endpoint) o Related sensitivity endpoint:, as confirmed by ultrasound (time to event)

Interventions

Sponsors

Universitair Ziekenhuis Gent
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to 64 Years

Design outcomes

Primary

MeasureTime frame
the probability of having at least one good quality blastocyst after ART (on the day of embryo transfer) (binary endpoint).

Secondary

MeasureTime frame
the relative number of blastocyts after ART (on the day of embryo transfer), relative to the number of oocytes (rate), the probability of having at least one blastocyst of good quality after ART (on the day of embryo transfer) (binary endpoint), the probability of having an ongoing pregnancy which is defined as 6 to 8 weeks gestational age (binary endpoint) o Related sensitivity endpoint:, as confirmed by ultrasound (time to event)

Countries

Belgium

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026