Renal Outcomes in the early use of vasopressin in the treatment of septic shock

Conditions

Septic shock

Brief summary

30% reduction of patients satisfying the criteria for CRRT within the study group.

Detailed description

Reduction of maximum KDIGO class reached in the first 7 days of hospitalization, Evaluation of renal perfusion using the CEUS method carried out within 24 hours of enrollment and 72 hours after the first evaluation (in terms of the presence of ischemic areas, their number and size, Water balance 24, 48, 72 hours after admission to the ICU, Number of patients meeting criteria for RRT during ICU stay, Number of patients who develop AF, atrial flutter or PSVT lasting more than 30 minutes and who require the introduction of new drugs for rate or rhythm control or electrical cardioversion within 24 hours of arrhythmic onset, Number of patients who present intestinal ischemia or extremity ischemia during the infusion of vasoactive drugs or within 3 days after the end of the administration of the aforementioned drugs, Length of stay in ICU and mortality at 28 and 90 days

Related papers

No related papers found yet.

Interventions

DRUGSonoVue 8 microlitres/mL powder and solvent for dispersion for injection

DRUGEmpressin 40 I.U./2 ml concentrato per soluzione per infusione

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
30% reduction of patients satisfying the criteria for CRRT within the study group.	—

Secondary

Measure	Time frame
Reduction of maximum KDIGO class reached in the first 7 days of hospitalization, Evaluation of renal perfusion using the CEUS method carried out within 24 hours of enrollment and 72 hours after the first evaluation (in terms of the presence of ischemic areas, their number and size, Water balance 24, 48, 72 hours after admission to the ICU, Number of patients meeting criteria for RRT during ICU stay, Number of patients who develop AF, atrial flutter or PSVT lasting more than 30 minutes and who require the introduction of new drugs for rate or rhythm control or electrical cardioversion within 24 hours of arrhythmic onset, Number of patients who present intestinal ischemia or extremity ischemia during the infusion of vasoactive drugs or within 3 days after the end of the administration of the aforementioned drugs, Length of stay in ICU and mortality at 28 and 90 days	—

Measure

Time frame

Reduction of maximum KDIGO class reached in the first 7 days of hospitalization, Evaluation of renal perfusion using the CEUS method carried out within 24 hours of enrollment and 72 hours after the first evaluation (in terms of the presence of ischemic areas, their number and size, Water balance 24, 48, 72 hours after admission to the ICU, Number of patients meeting criteria for RRT during ICU stay, Number of patients who develop AF, atrial flutter or PSVT lasting more than 30 minutes and who require the introduction of new drugs for rate or rhythm control or electrical cardioversion within 24 hours of arrhythmic onset, Number of patients who present intestinal ischemia or extremity ischemia during the infusion of vasoactive drugs or within 3 days after the end of the administration of the aforementioned drugs, Length of stay in ICU and mortality at 28 and 90 days

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Countries

Italy

Outcome results

None listed