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A multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 2 trial to evaluate the efficacy and safety of BP1.7881 in adult patients with eosinophilic esophagitis.

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2023-508949-40-00
Acronym
P22-04 / BP1.7881
Enrollment
24
Registered
2024-06-26
Start date
2024-11-29
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eosinophilic esophagitis

Brief summary

Proportion of patients achieving peak esophageal intraepithelial eosinophil count of ≤6 eos/hpf at week 12.

Detailed description

Change in total EoE-Dysphagia Assessment Questionnaire (EDAQ) score from baseline to week 12., Change inEosinophilic Esophagitis-Endoscopic Reference Score (EoE-EREFS) from baseline to week 12., Percent change in peak esophageal intraepithelial eosinophil count (eos/hpf)., Change in EoE Grade Score from the Histology Scoring System (EoE-HSS) from baseline to week 12., Change in EoE Stage Score from the EoE-HSS from baseline to week 12.

Interventions

DRUGMatching orodispersible placebo tablet

Sponsors

Bioprojet Pharma
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Proportion of patients achieving peak esophageal intraepithelial eosinophil count of ≤6 eos/hpf at week 12.

Secondary

MeasureTime frame
Change in total EoE-Dysphagia Assessment Questionnaire (EDAQ) score from baseline to week 12., Change inEosinophilic Esophagitis-Endoscopic Reference Score (EoE-EREFS) from baseline to week 12., Percent change in peak esophageal intraepithelial eosinophil count (eos/hpf)., Change in EoE Grade Score from the Histology Scoring System (EoE-HSS) from baseline to week 12., Change in EoE Stage Score from the EoE-HSS from baseline to week 12.

Countries

France, Italy

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026