Patients hospitalised in intensive care, diagnosed with sepsis less than 48 hours ago, uric acid level ≥200µmol/L, adults, negative G6PD deficiency
Conditions
Brief summary
Worsening of renal function defined by at least one of the following: The onset of acute kidney injury (AKI) within 7 days of inclusion. Non-improvement or progression of the stage of AKI according to KDIGO criteria on the 7th day after inclusion
Detailed description
Death rate at D28 and D90, The maximum SOFA score during the first 7 days, The evolution of renal aggression markers (N-GAL, Pro-enkephalin, IL-18) in blood and urine at D0, D3, and D7, The evolution of the leukocyte rate, pro- and anti-inflammatory cytokines (TNFα, IL-1, 6, 8, 10) at D1, D3, and D7
Interventions
DRUGPlacebo de fasturtec
Sponsors
Assistance Publique Hopitaux De Paris
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Worsening of renal function defined by at least one of the following: The onset of acute kidney injury (AKI) within 7 days of inclusion. Non-improvement or progression of the stage of AKI according to KDIGO criteria on the 7th day after inclusion | — |
Secondary
| Measure | Time frame |
|---|---|
| Death rate at D28 and D90, The maximum SOFA score during the first 7 days, The evolution of renal aggression markers (N-GAL, Pro-enkephalin, IL-18) in blood and urine at D0, D3, and D7, The evolution of the leukocyte rate, pro- and anti-inflammatory cytokines (TNFα, IL-1, 6, 8, 10) at D1, D3, and D7 | — |
Countries
France
Outcome results
None listed