Chronic rhinosinusitis with nasal polyps (CRSwNP)
Conditions
Brief summary
Identification of cell/molecular biomarkers correlated with individual patients’ responses. These could be: frequencies of cell (sub)populations, gene expression pattern, cell activation statues/phenotype, expression/production pattern of cell products, Identification of immunological mechanisms behind responses to mepolizumab, Evidence for the effectiveness in in vitro setting of mepolizumab in certain CRSsNP patients / endotypes
Detailed description
For CRSwNP group: Change in SNOT-22 from baseline to 6 months post-treatment
Interventions
Sponsors
Amsterdam UMC
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification of cell/molecular biomarkers correlated with individual patients’ responses. These could be: frequencies of cell (sub)populations, gene expression pattern, cell activation statues/phenotype, expression/production pattern of cell products, Identification of immunological mechanisms behind responses to mepolizumab, Evidence for the effectiveness in in vitro setting of mepolizumab in certain CRSsNP patients / endotypes | — |
Secondary
| Measure | Time frame |
|---|---|
| For CRSwNP group: Change in SNOT-22 from baseline to 6 months post-treatment | — |
Countries
Netherlands
Outcome results
None listed