Brain effects of hormonal contraceptives. A randomized, double-blind, longitudinal study comparing two combined oral contraceptives (Estetrol/drospirenone vs ethinylestradiol/levonorgestrel).

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

EU CTIS

Registry ID

CTIS2023-507842-10-00

Enrollment

Registered

2024-01-18

Start date

2024-03-18

Completion date

2025-06-08

Last updated

2024-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Contraception

Brief summary

Change from baseline to treatment in grey matter volume grey matter surface and gyrification, white matter integrity and connectivity (DTI), resting state activity and reactivity during emotion processing

Detailed description

Change in DRSP score between baseline and treatment, Change in Quality of Life between baseline and treatment, Change in depressive symptoms and anxiety symptoms from baseline

Interventions

DRUGDROSPIRENONE AND ESTETROL

DRUGLEVONORGESTREL AND ETHINYLESTRADIOL

Eligibility

Sex/Gender

All

Age

18 Years to 64 Years

Design outcomes

Primary

Measure	Time frame
Change from baseline to treatment in grey matter volume grey matter surface and gyrification, white matter integrity and connectivity (DTI), resting state activity and reactivity during emotion processing	—

Secondary

Measure	Time frame
Change in DRSP score between baseline and treatment, Change in Quality of Life between baseline and treatment, Change in depressive symptoms and anxiety symptoms from baseline	—

Countries

Sweden

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026