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An open-label, multicenter, prospective, single-arm, exploratory study to assess role of pancreatic enzyme replacement therapy (PERT) (Creon® 25,000) in patients with Pancreatic Exocrine Insufficiency (PEI) after total gastrectomy.

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2023-507837-18-00
Enrollment
60
Registered
2025-01-15
Start date
2025-03-06
Completion date
Unknown
Last updated
2026-01-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male and female patients aged ≥ 18 to ≤ 80 after total gastrectomy.

Brief summary

Proportion of patients on stable dose of Creon, in whom there is no deterioration of nutritional status (as measured by no loss of body weight from baseline Visit).

Detailed description

Change in bodyweight from baseline, Percentage of patients who develop symptomatic pancreatic exocrine insufficiency after gastrectomy., Symptoms of pancreatic exocrine insufficiency measured (as recorded in subject diaries), Nutritional parameters, Gastrointestinal Quality of life index (GIQLI) questionnaire, Treatment Emergent Adverse Events (TEAEs), Change in vital signs

Interventions

DRUGCreon® 25000 Capsules

Sponsors

BGP Products Operations GmbH
Lead SponsorINDUSTRY

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Proportion of patients on stable dose of Creon, in whom there is no deterioration of nutritional status (as measured by no loss of body weight from baseline Visit).

Secondary

MeasureTime frame
Change in bodyweight from baseline, Percentage of patients who develop symptomatic pancreatic exocrine insufficiency after gastrectomy., Symptoms of pancreatic exocrine insufficiency measured (as recorded in subject diaries), Nutritional parameters, Gastrointestinal Quality of life index (GIQLI) questionnaire, Treatment Emergent Adverse Events (TEAEs), Change in vital signs

Countries

Poland, Portugal, Spain

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026