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Clinical Surveillance vs. Anticoagulation for Low-risk Patients with Isolated Subsegmental Pulmonary Embolism: A Multicenter Randomized Placebo-Controlled Non-Inferiority Trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2023-507801-32-00
Acronym
SAFE-SSPE
Enrollment
134
Registered
2023-10-27
Start date
2021-07-07
Completion date
Unknown
Last updated
2025-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Isolated Subsegmental Pulmonary Embolism

Brief summary

The primary outcome will be the proportion of recurrent, clinically symptomatic, objectively confirmed VTE within 90 days of randomization, defined as recurrent fatal or nonfatal pulmonary embolism (PE) or lower limb deep vein thrombosis (DVT; efficacy).

Detailed description

The secondary outcomes will be the proportion of clinically significant bleeding and all-cause mortality at 90 days of randomization (safety)., The ancillary outcomes will be health-related quality of life, functional status, and medical resource utilization at 90 days of randomization.

Interventions

DRUGPlacebo for BAY 597939
DRUGRivaroxaban Bayer

Sponsors

Insel Gruppe AG
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
The primary outcome will be the proportion of recurrent, clinically symptomatic, objectively confirmed VTE within 90 days of randomization, defined as recurrent fatal or nonfatal pulmonary embolism (PE) or lower limb deep vein thrombosis (DVT; efficacy).

Secondary

MeasureTime frame
The secondary outcomes will be the proportion of clinically significant bleeding and all-cause mortality at 90 days of randomization (safety)., The ancillary outcomes will be health-related quality of life, functional status, and medical resource utilization at 90 days of randomization.

Countries

Belgium, France, Netherlands

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026