Alzheimer’s Disease
Conditions
Brief summary
diagnostic capabilities (sensitivity, specificity and AUC) of oculometry (pupillary response, number, latency and amplitude of ocular saccades), functional MRI (LC-hippocampus and LC-prefrontal cortex) and structural MRI (LC intensity) for a positive PET-Tau exam.
Detailed description
The diagnostic capabilities (sensitivity, specificity and AUC) of each of the elements of oculometry (pupillary response, number, latency and amplitude of ocular saccades), functional MRI (LC-hippocampus and LC-prefrontal cortex) and structural MRI (LC intensity) for a positive PET-Tau examination will be evaluated separately for the APOe4- and APOe4+ groups, The relationship between different LC biomarkers (PET, MRI, pupillometry)., The reliability of pupillometry and oculometry measurements will be validated by retesting a subgroup of 30 participants 1 to 4 weeks apart., The link between PET Tau uptake and changes at 12 and 24 months in pupillometry, oculometry and the structural (neuromelanin) and functional integrity of the LC measured on MRI will be assessed by correlating variations expressed as absolute values or as a proportion of the baseline value with PET Tau, and by regression., The link between variations in pupillometry, oculometry and the structural (neuromelanin) and functional integrity of the LC measured on MRI at 12 and 24 months will be evaluated by correlation between variations expressed as absolute values or as a proportion of the baseline value and by regression, The relationship between the various LC biomarkers (PET, MRI, pupillometry) and participants' cognitive performance will be assessed both at inclusion and at 12 and 24 months, using regressions that take into account age, gender, level of education and APOe4 status., All items will be compared between APOe4+ and APOe4- groups.a) Structural (neuromelanin) and functional integrity of the LC measured by MRI. b) Cognitive performance. c) Pupillometry and oculometry. d) And their evolution at 12 and 24 months.
Interventions
DRUG18F-Flortaucipir
Sponsors
Centre Hospitalier Universitaire De Toulouse
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| diagnostic capabilities (sensitivity, specificity and AUC) of oculometry (pupillary response, number, latency and amplitude of ocular saccades), functional MRI (LC-hippocampus and LC-prefrontal cortex) and structural MRI (LC intensity) for a positive PET-Tau exam. | — |
Secondary
| Measure | Time frame |
|---|---|
| The diagnostic capabilities (sensitivity, specificity and AUC) of each of the elements of oculometry (pupillary response, number, latency and amplitude of ocular saccades), functional MRI (LC-hippocampus and LC-prefrontal cortex) and structural MRI (LC intensity) for a positive PET-Tau examination will be evaluated separately for the APOe4- and APOe4+ groups, The relationship between different LC biomarkers (PET, MRI, pupillometry)., The reliability of pupillometry and oculometry measurements will be validated by retesting a subgroup of 30 participants 1 to 4 weeks apart., The link between PET Tau uptake and changes at 12 and 24 months in pupillometry, oculometry and the structural (neuromelanin) and functional integrity of the LC measured on MRI will be assessed by correlating variations expressed as absolute values or as a proportion of the baseline value with PET Tau, and by regression., The link between variations in pupillometry, oculometry and the structural (neuromelanin) and fu | — |
Countries
France
Outcome results
None listed