A pilot single center, open label trial to assess the impact of doxycycline postexposure prophylaxis on antimicrobial resistance

Conditions

Bacterial sexually transmittable diseases (chlamydia, gonorrhea, syphilis)

Brief summary

Shift in the distribution of minimum inhibitory concentration (MIC) of doxycycline in rectal E. coli on day 180.

Detailed description

Shift in the distribution of MIC of ceftriaxone in rectal E. coli on day 180., Shift in the distribution ofMIC of ciprofloxacin in rectal E. coli on day 180., Shift in the distribution of MIC of doxycycline in rectal K. pneumoniae on day 180., Shift in the distribution of MIC of ceftriaxone in rectal K. pneumoniae on day 180, Shift in the distribution of MIC of ciprofloxacin in rectal K. pneumoniae on day 180, Shift in the distribution of MIC of doxycycline in oral streptococci on day 180, Shift in the distribution of MIC of ceftriaxone in oral streptococci on day 180, Shift in the distribution of MIC of ciprofloxacin in oral streptococci on day 180, Shift in the distribution of MIC of doxycycline in oral S. aureus on day 180, Shift in the distribution of MIC of ceftriaxone in oral S. aureus on day 180, Shift in the distribution of MIC of ciprofloxacin in oral S. aureus on day 180, Shift in the distribution of MIC of doxycycline in oral commensal Neisseria spp. on day 180, Shift in the distribution of MIC of ceftriaxone in oral commensal Neisseria spp. on day 180, Shift in the distribution of MIC of ciprofloxacin in oral commensal Neisseria spp. on day 180

Related papers

No related papers found yet.

Interventions

DRUGDoxycycline EG 200 mg Tabletten

Eligibility

Sex/Gender

Male

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Shift in the distribution of minimum inhibitory concentration (MIC) of doxycycline in rectal E. coli on day 180.	—

Secondary

Measure	Time frame
Shift in the distribution of MIC of ceftriaxone in rectal E. coli on day 180., Shift in the distribution ofMIC of ciprofloxacin in rectal E. coli on day 180., Shift in the distribution of MIC of doxycycline in rectal K. pneumoniae on day 180., Shift in the distribution of MIC of ceftriaxone in rectal K. pneumoniae on day 180, Shift in the distribution of MIC of ciprofloxacin in rectal K. pneumoniae on day 180, Shift in the distribution of MIC of doxycycline in oral streptococci on day 180, Shift in the distribution of MIC of ceftriaxone in oral streptococci on day 180, Shift in the distribution of MIC of ciprofloxacin in oral streptococci on day 180, Shift in the distribution of MIC of doxycycline in oral S. aureus on day 180, Shift in the distribution of MIC of ceftriaxone in oral S. aureus on day 180, Shift in the distribution of MIC of ciprofloxacin in oral S. aureus on day 180, Shift in the distribution of MIC of doxycycline in oral commensal Neisseria spp. on day 180, Shift in the	—

Measure

Time frame

Shift in the distribution of MIC of ceftriaxone in rectal E. coli on day 180., Shift in the distribution ofMIC of ciprofloxacin in rectal E. coli on day 180., Shift in the distribution of MIC of doxycycline in rectal K. pneumoniae on day 180., Shift in the distribution of MIC of ceftriaxone in rectal K. pneumoniae on day 180, Shift in the distribution of MIC of ciprofloxacin in rectal K. pneumoniae on day 180, Shift in the distribution of MIC of doxycycline in oral streptococci on day 180, Shift in the distribution of MIC of ceftriaxone in oral streptococci on day 180, Shift in the distribution of MIC of ciprofloxacin in oral streptococci on day 180, Shift in the distribution of MIC of doxycycline in oral S. aureus on day 180, Shift in the distribution of MIC of ceftriaxone in oral S. aureus on day 180, Shift in the distribution of MIC of ciprofloxacin in oral S. aureus on day 180, Shift in the distribution of MIC of doxycycline in oral commensal Neisseria spp. on day 180, Shift in the

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Countries

Belgium

Outcome results

None listed